Cardiac stem cells (CSCs) represent a logical cell type to exploit as a regenerative treatment
option for tissue damage accrued as a result of a myocardial infarction. However, the …

Acute ischemic injury and chronic cardiomyopathies damage healthy heart tissue. Dead
cells are gradually replaced by a fibrotic scar, which disrupts the normal electromechanical …

Background—Under normoxic conditions, hypoxia-inducible factor (HIF)-1α is rapidly
degraded by 2 hydroxylases: prolyl hydroxylase (PHD) and factor-inhibiting HIF-1 (FIH) …

In 2001, a research team published 2 high-profile reports1, 2 suggesting that bone marrow
could regenerate the heart and new myocytes are formed in the human heart at a substantial …

Cardiac inflammation is considered by many as the main driving force in prolonging the
pathological condition in the heart after myocardial infarction. Immediately after cardiac …

Rationale: The adult heart possesses a pool of progenitor cells stored in myocardial niches,
but the mechanisms involved in the activation of this cell compartment are currently …

Opinion statement The discovery of adult cardiac stem cells (CSCs) and their potential to
restore functional cardiac tissue has fueled unprecedented interest in recent years. Indeed …

Growth factors regulated by specific macronutrients have been shown to promote aging and
accelerate mortality in the majority of the organisms studied. In particular, the enzymes …

Research has demonstrated that hypoxic preconditioning (HP) can enhance the survival
and proliferation of cardiac progenitor cells (CPCs); however, the underlying mechanisms …

Purpose Cardiac pathologies remain a dominant cause of morbidity and mortality within the
community. The drive to develop therapies capable of repairing damaged heart tissue to …