Origins of lifetime health around the time of conception: causes and consequences

TP Fleming, AJ Watkins, MA Velazquez, JC Mathers… - The Lancet, 2018 - thelancet.com
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

[HTML][HTML] Obesity as disruptor of the female fertility

E Silvestris, G De Pergola, R Rosania… - Reproductive Biology and …, 2018 - Springer
Both obesity and overweight are increasing worldwide and have detrimental influences on
several human body functions including the reproductive health. In particular, obese women …

[HTML][HTML] Obesity induces ovarian inflammation and reduces oocyte quality

AP Snider, JR Wood - Reproduction, 2019 - rep.bioscientifica.com
In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

[HTML][HTML] Single-cell reconstruction of follicular remodeling in the human adult ovary

X Fan, M Bialecka, I Moustakas, E Lam… - Nature …, 2019 - nature.com
The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …

[HTML][HTML] Female obesity and infertility: outcomes and regulatory guidance

S Marinelli, G Napoletano, M Straccamore… - Acta Bio Medica …, 2022 - ncbi.nlm.nih.gov
Obesity has been associated with reduced fertility, although the dynamics and mechanisms
which link excess weight to reduced fertility are not yet fully clarified. Obese women …

[HTML][HTML] Maternal low-grade chronic inflammation and intrauterine programming of health and disease

F Parisi, R Milazzo, VM Savasi, I Cetin - International journal of molecular …, 2021 - mdpi.com
Overweight and obesity during pregnancy have been associated with increased birth
weight, childhood obesity, and noncommunicable diseases in the offspring, leading to a …

[HTML][HTML] Deciphering metabolic heterogeneity by single-cell analysis

TMJ Evers, M Hochane, SJ Tans, RMA Heeren… - 2019 - ACS Publications
Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual
cells. This Feature highlights recent developments in key analytical techniques suited for …

[HTML][HTML] A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver …

A Ullah, A Ud Din, W Ding, Z Shi, S Pervaz… - Reviews in Endocrine …, 2023 - Springer
Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …

[HTML][HTML] New insights and potential therapeutic interventions in metabolic diseases

VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Endocrine homeostasis and metabolic diseases have been the subject of extensive
research in recent years. The development of new techniques and insights has led to a …

Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights

MB Gonzalez, RL Robker, RD Rose - Biology of reproduction, 2022 - academic.oup.com
The prevalence of obesity in adults worldwide, and specifically in women of reproductive
age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes …