The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria

Y Zhang, FEC Jen, KL Fox, JL Edwards… - Trends in …, 2023 - cell.com
Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first
thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP …

Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria

T Shiraishi, S Yokota, S Fukiya… - Bioscience of microbiota …, 2016 - jstage.jst.go.jp
Bacterial cell surface molecules are at the forefront of host-bacterium interactions. Teichoic
acids are observed only in Gram-positive bacteria, and they are one of the main cell surface …

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

N Heß, F Waldow, TP Kohler, M Rohde… - Nature …, 2017 - nature.com
Teichoic acid (TA), a crucial cell wall constituent of the pathobiont Streptococcus
pneumoniae, is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane …

Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall

D Straume, KW Piechowiak, S Olsen… - Proceedings of the …, 2020 - National Acad Sciences
In oval-shaped Streptococcus pneumoniae, septal and longitudinal peptidoglycan
syntheses are performed by independent functional complexes: the divisome and the …

Phosphatidylcholine biosynthesis in mitis group streptococci via host metabolite scavenging

LR Joyce, Z Guan, KL Palmer - Journal of bacteriology, 2019 - Am Soc Microbiol
The mitis group streptococci include the major human pathogen Streptococcus pneumoniae
and the opportunistic pathogens Streptococcus mitis and Streptococcus oralis, which are …

Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for …

Y Zhang, FEC Jen, JL Edwards… - Microbiology …, 2023 - Am Soc Microbiol
Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine
(ChoP), which contributes to host mimicry and can also promote colonization and survival in …

Scalable Synthesis of Versatile Rare Deoxyamino Sugar Building Blocks from d-Glucosamine

D Dhara, M Bouchet, LA Mulard - The Journal of Organic …, 2023 - ACS Publications
We report the syntheses of 1, 3, 4-tri-O-acetyl-2-amino-2, 6-dideoxy-β-d-glucopyranose and
allyl 2-amino-2, 6-dideoxy-β-d-glucopyranoside from d-glucosamine hydrochloride. The …

Total Synthesis of the Lipid-Anchor-Attached Core Trisaccharides of Lipoteichoic Acids of Streptococcus pneumoniae and Streptococcus oralis Uo5

BK Ghotekar, AR Podilapu, SS Kulkarni - Organic letters, 2019 - ACS Publications
Herein we report an efficient total synthesis of lipid-anchor-appended core trisaccharides of
lipoteichoic acids of Streptococcus pneumoniae and Streptococcus oralis Uo5. The key …

Structural analysis and immunostimulatory potency of lipoteichoic acids isolated from three Streptococcus suis serotype 2 strains

N Gisch, JP Auger, S Thomsen, D Roy, J Xu… - Journal of Biological …, 2018 - ASBMB
Streptococcus suis serotype 2 is an important porcine and human pathogen. Lipoteichoic
acid (LTA) from S. suis has been suggested to contribute to its virulence, and absence of d …

Streptococcus pneumoniae, S. mitis, and S. oralis Produce a Phosphatidylglycerol-Dependent, ltaS-Independent Glycerophosphate-Linked Glycolipid

Y Wei, LR Joyce, AM Wall, Z Guan, KL Palmer - Msphere, 2021 - Am Soc Microbiol
Lipoteichoic acid (LTA) is a Gram-positive bacterial cell surface polymer that participates in
host-microbe interactions. It was previously reported that the major human pathogen …