The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Objective: This review consists of three parts, representing three different possibilities of
interactions between cannabinoid receptor ligands of both exogenous and endogenous …

The combination of aging populations with the obesity pandemic results in an alarming rise
in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor …

There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …

G protein–coupled receptors (GPCRs) compose one of the largest families of membrane
proteins involved in intracellular signaling. They are involved in numerous physiological and …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …