The human gut microbiome is the ecosystem of microorganisms that live in the human
digestive system. Several studies have related gut microbiome variants to metabolic …

Abstract Background and Hypotheses Social dysfunction in schizophrenia includes
symptoms of withdrawal and deficits in social skills, social cognition, and social motivation …

Recent data suggest that defects in purinergic signalling are a common denominator of
autism spectrum disorders (ASDs), though nothing is known about whether the disorder …

Autism spectrum disorder (ASD) is characterized by deficits in communication and social
interaction, restricted interests, and stereotyped behavior. Environmental factors, such as …

Abstract Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used drugs for the
treatment of psychiatric diseases including major depressive disorder (MDD). For unknown …

Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the
abnormal persistence of a normal, alternative functional state of mitochondria? A small …

Introduction The integrity of the intestinal epithelium is crucial for human health and is
harmed in autism spectrum disorder (ASD). An aberrant gut microbial composition resulting …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing
prevalence. Over 1,000 risk genes have now been implicated in ASD, suggesting diverse …

ABSTRACT Introduction: Pharmacologic interventions in Autism Spectrum Disorder (ASD)
have historically focused on symptom-based approaches. However, a treatment for the core …

Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing
numerous protein substrates for proteasomal degradation. Key to CRL activity is the …