Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy
characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular …

Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play
an important role in the eye to regulate the homeostasis and even to treat some ocular …

In the 1980s, researchers used binding studies to show that there is a melatonin binding site
in addition to the receptors described previously. It was first termed ML2 and then, in 1999 …

The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …

Melatonin is not only synthesized by the pineal gland but by several ocular structures. This
natural indoleamine is of great importance for regulating several eye processes, among …

Introduction: Glaucoma is one of the main leading causes of irreversible blindness in the
world. The treatment of this disease relies on the use of drugs able to reduce/control the …

Purpose Agomelatine is an agonist of melatonin that is used in the treatment of major
depressive disorders. It has also shown an ability to decrease IOP in experiment animals …

Glaucoma is a heterogeneous group of progressive diseases that leads to irreversible
blindness. Secondary glaucoma refers to glaucoma caused by a known underlying …

Melatonin is a neurohormone that is produced not only by the pineal gland but also by
several ocular structures. One of the main physiologic roles of melatonin is the reduction of …

Melatonin is of great importance for regulating several eye processes, including pressure
homeostasis. Melatonin in combination with agomelatine has been recently reported to …