The majority of US adult cancer patients today are diagnosed and treated outside the
context of any clinical trial (that is, in the real world). Although these patients are not part of a …

Objective Electronic health records (EHRs) are a promising source of data for health
outcomes research in oncology. A challenge in using EHR data is that selecting cohorts of …

The rarity and heterogeneity of sarcomas make performing appropriately powered studies
challenging and magnify the significance of large databases in sarcoma research …

The role of real‐world evidence (RWE) in regulatory, drug development, and healthcare
decision‐making is rapidly expanding. Recent advances have increased the complexity of …

Introduction Real-world evidence derived from electronic health records (EHRs) is
increasingly recognized as a supplement to evidence generated from traditional clinical …

Importance The US Food and Drug Administration (FDA) is increasing its pace of approvals
for novel cancer therapeutics, including for immune checkpoint inhibitors of programmed cell …

Advances in machine learning (ML) and artificial intelligence offer tremendous potential
benefits to patients. Predictive analytics using ML are already widely used in healthcare …

Evidence from real-world clinical settings is lacking with regard to first-line immunotherapy
plus chemotherapy for the treatment of non-small cell lung cancer (NSCLC). Our aim was to …

Background Evidence from cancer clinical trials can be difficult to generalize to real‐world
patient populations, but can be complemented by real‐world evidence to optimize …

Background Evidence from cancer clinical trials has strong internal validity but can be
difficult to generalize to real‐world patient populations. Here we analyzed real‐world …