In the United States in the period 1973–1997, the incidence and mortality due to large bowel
cancer was higher in blacks than in other ethnic groups. The incidence in blacks in the …

Background Randomised trials have shown that aspirin reduces the short-term risk of
recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large …

ContextRandomized trials of short-term aspirin use for prevention of recurrent colorectal
adenoma have provided compelling evidence of a causal relationship between aspirin and …

Background Epidemiological studies have clarified the potential associations between
regular aspirin use and cancers. However, it remains controversial on whether aspirin use …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

We comprehensively reviewed the published scientific literature on non-steroidal anti-
inflammatory drugs (NSAIDs) and cancer and evaluated results based upon epidemiologic …

Several lines of evidence suggest that cyclooxygenase-2 (COX-2) is a rational target for
anticancer therapy. Epidemiological studies have shown that use of nonsteroidal anti …

Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …

Calcium homeostasis is a tightly regulated process involving the co-ordinated efforts of the
skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis …

Although traditional medicines have been used for thousands of years, for most such
medicines neither the active component nor their molecular targets have been very well …