Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice
AE Moran, DH Hunt, SH Javid, M Redston… - Journal of Biological …, 2004 - ASBMB
Overexpression of the epidermal growth factor receptor (EGFR) and its increased tyrosine
kinase activity are implicated in colorectal cancer (CRC) development and malignant …
kinase activity are implicated in colorectal cancer (CRC) development and malignant …
Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
RE Harris, J Beebe-Donk, GA Alshafie - BMC cancer, 2008 - Springer
Background Epidemiologic and laboratory investigations suggest that aspirin and other
nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon …
nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon …
Aspirin and nonaspirin nonsteroidal antiinflammatory drug use and occurrence of colorectal adenoma in Black American women
LE Barber, KA Bertrand, S Sheehy… - … journal of cancer, 2023 - Wiley Online Library
Evidence suggests that aspirin use reduces the occurrence of colorectal neoplasia. Few
studies have investigated the association among Black Americans, who are …
studies have investigated the association among Black Americans, who are …
Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
JY Wang, BK Chen, YS Wang, YT Tsai, WC Chen… - Cellular signalling, 2012 - Elsevier
Growing evidence shows that chronic inflammation drives the progression of colorectal
cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes …
cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes …
Celecoxib, a cyclooxygenase-2 inhibitor, reduces neointimal hyperplasia through inhibition of Akt signaling
HM Yang, HS Kim, KW Park, HJ You, SI Jeon… - Circulation, 2004 - Am Heart Assoc
Background—Celecoxib has been shown to have antitumor effects that may be mediated
through the cyclooxygenase-independent inhibition of Akt signaling. Here, we examined the …
through the cyclooxygenase-independent inhibition of Akt signaling. Here, we examined the …
COX-2 inhibition as a tool to treat and prevent colorectal cancer
JB Tuynman, MP Peppelenbosch, DJ Richel - Critical reviews in oncology …, 2004 - Elsevier
The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer
Background Eighty percent of all breast cancers and almost 90% of breast cancer deaths
occur among post-menopausal women. We used a nested case control design to examine …
occur among post-menopausal women. We used a nested case control design to examine …
Potential role of flavonoids in the prevention of intestinal neoplasia: a review of their mode of action and their clinical perspectives
HP Hoensch, W Kirch - International Journal of Gastrointestinal Cancer, 2005 - Springer
Intestinal neoplasia (adenomas and carcinomas) can possibly be prevented by a diet rich in
vegetables and fruits, treatment with aspirin and other nonsteroidal antiinflammatory drugs …
vegetables and fruits, treatment with aspirin and other nonsteroidal antiinflammatory drugs …
Cyclooxygenase-2: how good is it as a target for cancer chemoprevention?
MA Hull - European Journal of Cancer, 2005 - Elsevier
There is now substantial evidence for a role for cyclooxygenase-2 (COX-2)-mediated
prostaglandin (PG) signalling during carcinogenesis in a number of tissues and selective …
prostaglandin (PG) signalling during carcinogenesis in a number of tissues and selective …