Our work has identified a cancer-specific, cell surface and growth-related quinol oxidase
with both NADH oxidase and protein disulfide-thiol interchange activities, a member of the …

The objective of the present study was to determine the influence of cyclooxygenase-2 (COX-
2) inhibition by Celecoxib (CLX) in humans with distal colorectal adenocarcinoma (CRC) on …

COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates
prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance …

Colorectal carcinoma is one of the commonest solid organ tumors in the world and its
prevalence appears to be increasing in Asia. Recently, there has been much interest in …

Introduction. Cyclooxygenase‐2 (COX‐2) expression is elevated in colorectal cancer (CRC).
However, data about the relation between COX‐2 expression and the impact on the biologic …

In the last years it became clear that the tumor microenvironment plays a major role in
neoplastic growth. Proteins secreted either by the malignant cells or by the tumor-associated …

Currently, combination chemotherapy represents the standard of care treatment for patients
with metastatic colorectal cancer in the United States. Despite recent improvements with the …

Chemoprevention of colorectal cancer involves the long-term use of pharmacologic agents
that can prevent neoplasms from developing in the large bowel. This new approach requires …

This study was performed to evaluate whether down-regulation of prostaglandin E 2 (PGE 2)
synthesis by celecoxib treatment is associated with inhibition of cell growth in human colon …

BACKGROUND AND AIM: Dietary polyethylene glycol (PEG) is extraordinarily potent in the
chemoprevention of experimental colon carcinogenesis. PEG is used to treat constipation in …