The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Huntington disease is an autosomal dominant inherited brain disorder that typically
becomes manifest in adulthood. Juvenile‐onset Huntington disease refers to approximately …

The age at onset of motor symptoms in Huntington's disease (HD) is driven by HTT CAG
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …

Genome-wide association studies (GWASs) of Huntington disease (HD) have identified six
DNA maintenance gene loci (among others) as modifiers and implicated a two step …

Huntington's disease (HD) is a complex progressive neurodegenerative disorder affected by
genetic, environmental, and metabolic factors contributing to its pathogenesis. Gut dysbiosis …

Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

A caregiver's all‐too‐familiar narrative‐“He doesn't think through what he does, but mostly
he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co …

Huntington's disease (HD) is a neurodegenerative disorder caused by a dominantly
inherited CAG repeat expansion in the huntingtin gene (HTT). Neuroinflammation and …

In Huntington's disease (HD), the main clinical symptoms include depression, apathy,
cognitive deficits, motor deficiencies and involuntary movements. Cognitive, mood and …

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …