Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …

Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

B cells occupy a vital role in the functioning of the immune system, working in tandem with T
cells to either suppress or promote tumor growth within the tumor microenvironment (TME) …

Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …

Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …