It has been established that 4.4 to 20% of the general population suffers from a major
depressive disorder (MDD), which is frequently associated with a dysregulation of normal …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

A growing body of literature suggests that sleep and emotions are closely linked, and that
the relationship between these two domains is complex and bidirectional. This review …

Objectives. This 2013 update of the practice guidelines for the biological treatment of
unipolar depressive disorders was developed by an international Task Force of the World …

JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …

Cognitive neuroscience continues to build meaningful connections between affective
behavior and human brain function. Within the biological sciences, a similar renaissance …

Rumination, defined as repetitive thinking about negative information, has been found to
lead to serious maladaptive consequences, including longer and more severe episodes of …

Major depressive disorder is one of the most common psychiatric illnesses in the United
States, with an estimated lifetime prevalence of up to 17%. 1 Affected individuals are at high …

This paper reviews a novel hypothesis about the functions of slow wave sleep—the synaptic
homeostasis hypothesis. According to the hypothesis, plastic processes occurring during …

Background: Of all the psychiatric disorders associated with insomnia, depression is the
most common. It has been estimated that 90% of patients with depression complain about …