[HTML][HTML] Adjuvant chemotherapy in elderly colorectal cancer patients

B Glimelius, E Osterman - Cancers, 2020 - mdpi.com
The value of adjuvant chemotherapy in elderly patients has been the subject of many
overviews, with opinions varying from “not effective”, since randomized trials have not been …

Prognostic impact of early treatment and oxaliplatin discontinuation in patients with stage III colon cancer: an ACCENT/IDEA pooled analysis of 11 adjuvant trials

C Gallois, Q Shi, JP Meyers, T Iveson… - Journal of Clinical …, 2023 - ingentaconnect.com
PURPOSE Oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer
(CC) for 6 months remains a standard in high-risk stage III patients. Data are lacking as to …

Decision-making in geriatric oncology: systemic treatment considerations for older adults with colon cancer

EB Moth, J Vardy, P Blinman - Expert Review of Gastroenterology & …, 2016 - Taylor & Francis
Introduction: Colon cancer is common and can be considered a disease of older adults with
more than half of cases diagnosed in patients aged over 70 years. Decision-making about …

[HTML][HTML] Preliminary tolerance analysis of adjuvant chemotherapy in older patients after resection of stage III colon cancer from the PRODIGE 34-FFCD randomized …

T Aparicio, O Bouché, PL Etienne, E Barbier… - Digestive and Liver …, 2023 - Elsevier
Background Colon adenocarcinoma mainly occurs in older patients. Oxaliplatin-based
adjuvant chemotherapy improved disease-free survival after stage III colon cancer resection …

Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials

C Gallois, Q Shi, LD Pederson, T André… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE A number of studies suggest that older patients may have reduced or no benefit
from the addition of oxaliplatin to fluoropyrimidines as adjuvant chemotherapy for stage III …

Factors predicting adherence to a tailored-dose adjuvant treatment on the basis of geriatric assessment in elderly people with colorectal cancer: a prospective study

M Antonio, A Carmona-Bayonas, J Saldana… - Clinical colorectal …, 2018 - Elsevier
Background Selecting elderly people with colorectal cancer (CRC) for adjuvant
chemotherapy is challenging. Comprehensive geriatric assessment (CGA) can help by …

Early discontinuation and dose reduction of adjuvant chemotherapy in stage III colon cancer patients

D Boakye, L Jansen, N Halama… - Therapeutic …, 2021 - journals.sagepub.com
Background: The benefit of chemotherapy in colon cancer patients is well documented but
depends largely on whether patients complete the planned treatment regimen. We …

Prognostic factors of adjuvant chemotherapy discontinuation among stage III colon cancer patients: A survey of medical oncologists and a systematic review and meta …

DJ Boyne, DE O'Sullivan, EV Heer, RJ Hilsden… - Cancer …, 2020 - Wiley Online Library
Background Factors that are prognostic of early discontinuation of adjuvant chemotherapy
among stage III colon cancer patients have yet to be described. To address this gap, a …

Recurrence‐free and overall survival among elderly stage III colon cancer patients treated with CAPOX or capecitabine monotherapy

FN Van Erning, MLG Janssen‐Heijnen… - … journal of cancer, 2017 - Wiley Online Library
The aim of this study is to investigate the effects of CAPOX and capecitabine on recurrence‐
free survival (RFS) and overall survival (OS) among elderly stage III colon cancer patients …

Controversies in the multimodality management of locally advanced rectal cancer

R Díaz Beveridge, D Akhoundova, G Bruixola… - Medical Oncology, 2017 - Springer
Neoadjuvant radiotherapy previous to radical surgery, both as short-course radiotherapy
and as long-course radiotherapy combined with 5-FU-based chemotherapy (LCRCT), is …