The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

A picture is beginning to emerge from a variety of organisms that for a subset of genes, the
most important sequences that regulate expression are situated not in the promoter but …

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than
600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties …

Transcription is a source of genetic instability that can notably result from the formation of
genotoxic DNA: RNA hybrids, or R-loops, between the nascent mRNA and its template. Here …

The human nuclear poly (A)-binding protein PABPN1 has been implicated in the decay of
nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by …

Viruses have evolved diverse strategies to maximize the functional and coding capacities of
their genetic material. Individual viral RNAs are often used as substrates for both replication …

Cryptococcus neoformans, the most common cause of fungal meningitis, is a basidiomycete
haploid budding yeast with a complete sexual cycle. Genome modification by homologous …

Alternative transcription start site (TSS) usage regulation has been identified as a major
means of gene expression regulation in metazoans. However, in fungi, its impact remains …

The biological impact of alternative splicing is poorly understood in fungi, although recent
studies have shown that these microorganisms are usually intron-rich. In this study, we re …

Eukaryotic protein synthesis generally initiates at a start codon defined by an AUG and its
surrounding Kozak sequence context, but the quantitative importance of this context in …