Eukaryotic DNA polymerase δ is thought to consist of three (budding yeast) or four subunits
(fission yeast, mammals). Four human genes encoding polypeptides p125, p50, p66, and …

A 12-kDa and two 25-kDa polypeptides were isolated with highly purified calf thymus DNA
polymerase δ by conventional chromatography. A 16-mer peptide sequence was obtained …

In eukaryotes, DNA polymerase δ (pol δ) is responsible for replicating the lagging strand
template and anchors to the proliferating cell nuclear antigen (PCNA) sliding clamp to form a …

In eukaryotic cells, DNA transactions such as replication, repair, and transcription require a
large set of proteins. In all of these events, complexes of more than 30 polypetides appear to …

Proliferating cell nuclear antigen (PCNA) is an essential component of the DNA replication
and repair machinery in the domain Eucarya. We cloned the gene encoding a PCNA …

The DNA polymerase δ catalytic subunit gene (POLD1) was studied as a transcriptional
target of p53. Northern blotting showed that a significantly decreased steady-state level of …

The formation of a complex between DNA polymerase δ (pol δ) and its sliding clamp,
proliferating cell nuclear antigen (PCNA), is responsible for the maintenance of processive …

DNA polymerase δ (pol δ) plays an essential role in DNA replication, repair, and
recombination. We have purified pol δ from Schizosaccharomyces pombe more than 103 …

Proliferating cell nuclear antigen (PCNA) is required for processive DNA synthesis catalyzed
by DNA polymerase δ (pol δ) and polymerase ε. We have shown that the epitope of a human …

Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment
of cancer. However, there is no specific inhibitor of DNA polymerases that is viable for …