Mutations of key driver genes in colorectal cancer progression and metastasis

D Huang, W Sun, Y Zhou, P Li, F Chen, H Chen… - Cancer and Metastasis …, 2018 - Springer
The association between mutations of key driver genes and colorectal cancer (CRC)
metastasis has been investigated by many studies. However, the results of these studies …

The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer

GN Fanelli, CA Dal Pozzo, I Depetris, M Schirripa… - Cancer Cell …, 2020 - Springer
Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …

Current therapeutic strategies in BRAF-mutant metastatic colorectal cancer

E Grassi, J Corbelli, G Papiani, MA Barbera… - Frontiers in …, 2021 - frontiersin.org
Around 8–12% of patients with advanced colon rectal cancer (CRC) present with BRAF
alterations, in particular V600E mutation, which is associated with right-side, poorly …

[HTML][HTML] Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice

M Fassan, A Scarpa, A Remo, G De Maglio… - Pathologica, 2020 - ncbi.nlm.nih.gov
The pathologist emerged in the personalized medicine era as a central actor in the definition
of the most adequate diagnostic and therapeutic algorithms. In the last decade …

MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF (V600E) mutant colorectal cancer

Y Morimoto, N Yamashita, H Hirose, A Fushimi… - Cancer letters, 2023 - Elsevier
Colorectal cancers (CRCs) harboring the BRAF (V600E) mutation are associated with
aggressive disease and resistance to BRAF inhibitors by feedback activation of the receptor …

Meta-analysis of the molecular associations of mucinous colorectal cancer

IS Reynolds, SJ Furney, EW Kay… - Journal of British …, 2019 - academic.oup.com
Background Mucinous differentiation occurs in 5–15 per cent of colorectal
adenocarcinomas. This subtype of colorectal cancer responds poorly to chemoradiotherapy …

Radiomics Texture Features in Advanced Colorectal Cancer: Correlation with BRAF Mutation and 5-year Overall Survival

AA Negreros-Osuna, A Parakh, RB Corcoran… - Radiology: Imaging …, 2020 - pubs.rsna.org
Purpose To explore the potential of radiomics texture features as potential biomarkers to
enable detection of the presence of BRAF mutation and prediction of 5-year overall survival …

[HTML][HTML] BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications

V Angerilli, G Sabella, G Centonze, S Lonardi… - Critical Reviews in …, 2022 - Elsevier
Advances in molecular biology have markedly increased our understanding of the
heterogeneous molecular landscape of colorectal cancer (CRC). Up to 15% of CRCs harbor …

Risk factors for synchronous peritoneal metastases in colorectal cancer: a systematic review and meta-analysis

Y Zhang, X Qin, R Luo, H Wang, H Wang… - Frontiers in …, 2022 - frontiersin.org
Background Early detection of synchronous colorectal peritoneal metastases (CPMs) is
difficult due to the absence of typical symptoms and the low accuracy of imaging …

Mucinous adenocarcinoma of the colon and rectum: a genomic analysis

IS Reynolds, E O'Connell, M Fichtner… - Journal of surgical …, 2019 - Wiley Online Library
Abstract Background and Objectives Mucinous adenocarcinoma is a distinct subtype of
colorectal cancer (CRC) with a worse prognosis when compared with non‐mucinous …