An update on the use of image-derived input functions for human PET studies: new hopes or old illusions?

T Volpi, L Maccioni, M Colpo, G Debiasi, A Capotosti… - EJNMMI research, 2023 - Springer
Background The need for arterial blood data in quantitative PET research limits the wider
usability of this imaging method in clinical research settings. Image-derived input function …

Quantitation of dynamic total-body PET imaging: recent developments and future perspectives

F Gu, Q Wu - European Journal of Nuclear Medicine and Molecular …, 2023 - Springer
Background Positron emission tomography (PET) scanning is an important diagnostic
imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and …

Can internal carotid arteries be used for noninvasive quantification of Brain PET studies?

L Providência, CWJ van der Weijden… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Because of the limited axial field of view of conventional PET scanners, the internal carotid
arteries are commonly used to obtain an image-derived input function (IDIF) in quantitative …

[HTML][HTML] Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging

Y Zhu, Q Tran, Y Wang, RD Badawi, SR Cherry, J Qi… - Neuroimage, 2024 - Elsevier
Dynamic PET allows quantification of physiological parameters through tracer kinetic
modeling. For dynamic imaging of brain or head and neck cancer on conventional PET …

Non-invasive quantification of the brain [18F]FDG-PET using inferred blood input function learned from total-body data with physical constraint

Z Wang, Y Wu, Z Xia, X Chen, X Li, Y Bai… - … on Medical Imaging, 2024 - ieeexplore.ieee.org
Full quantification of brain PET requires the blood input function (IF), which is traditionally
achieved through an invasive and time-consuming arterial catheter procedure, making it …

Beyond stillness: the importance of tackling patient's motion for reliable parametric imaging

A Artesani, L Providência, J van Sluis… - European Journal of …, 2024 - Springer
Positron emission tomography (PET) is currently going through a technological revolution
marked by the introduction of long axial field of view (LAFOV) PET systems, advanced …

Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET

L Narciso, G Deller, P Dassanayake, L Liu, S Pinto… - EJNMMI physics, 2024 - Springer
Background Quantification of the cerebral metabolic rate of glucose (CMRGlu) by dynamic
[18F] FDG PET requires invasive arterial sampling. Alternatives to using an arterial input …

Evaluation of Non-Invasive Methods for (R)-[11C]PK11195 PET Image Quantification in Multiple Sclerosis

DBA Mantovani, MS Pitombeira, PN Schuck… - Journal of …, 2024 - mdpi.com
This study aims to evaluate non-invasive PET quantification methods for (R)-[11C] PK11195
uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in …

Parametric and non-parametric Poisson regression for modelling of the arterial input function in positron emission tomography

GJ Matheson, L Ge, M Zhang, B Sun, Y Tu, F Zanderigo… - EJNMMI physics, 2023 - Springer
Abstract Full quantification of Positron Emission Tomography (PET) requires an arterial input
function (AIF) for measurement of certain targets, or using particular radiotracers, or for the …

Kinetic analysis of cardiac dynamic 18F-Florbetapir PET in healthy volunteers and amyloidosis patients: A pilot study

H Wang, B Li, Z Wang, X Chen, Z You, YL Ng, Q Ge… - Heliyon, 2024 - cell.com
Objectives This study aimed to explore the potential of full dynamic PET kinetic analysis in
assessing amyloid binding and perfusion in the cardiac region using 18 F-Florbetapir PET …