Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect
DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide …

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …

Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jumping” from one genomic location to another, TEs are now recognized as …

DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

Transposable elements (TEs) comprise nearly half of the human genome and play an
essential role in the maintenance of genomic stability, chromosomal architecture, and …