Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

MQ Lian, WH Chng, J Liang, HQ Yeo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles
released by both animal and plant cells. These ubiquitous vesicles are involved in …

Recent applications of immunomodulatory biomaterials for disease immunotherapy

H Dai, Q Fan, C Wang - Exploration, 2022 - Wiley Online Library
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …

Advanced biomaterials for regulating polarization of macrophages in wound healing

J Mao, L Chen, Z Cai, S Qian, Z Liu… - Advanced Functional …, 2022 - Wiley Online Library
Macrophage immunotherapy is an emerging treatment strategy that modulates the immune
system to promote wound healing. The functionality and regeneration of tissue depend on …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

[HTML][HTML] Tea leaf-derived exosome-like nanotherapeutics retard breast tumor growth by pro-apoptosis and microbiota modulation

Q Chen, M Zu, H Gong, Y Ma, J Sun, S Ran… - Journal of …, 2023 - Springer
While several artificial nanodrugs have been approved for clinical treatment of breast tumor,
their long-term applications are restricted by unsatisfactory therapeutic outcomes, side …

Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Y Pu, X Fan, Z Zhang, Z Guo, Q Pan, W Gao… - Journal of Controlled …, 2023 - Elsevier
The inflammatory bowel disease (IBD) is incurable, chronic, recrudescent disorders in the
inflamed intestines. Current clinic treatments are challenged by systemic exposure-induced …

Plant exosome nanovesicles (PENs): green delivery platforms

M Cao, N Diao, X Cai, X Chen, Y Xiao, C Guo… - Materials …, 2023 - pubs.rsc.org
Natural plants have been gaining increasing attention in biomedical research due to their
numerous benefits. One of the plant's components, plant exosome-derived vesicles, are …

[HTML][HTML] The emerging role of plant-derived exosomes-like nanoparticles in immune regulation and periodontitis treatment

Z Zhang, Y Yu, G Zhu, L Zeng, S Xu, H Cheng… - Frontiers in …, 2022 - frontiersin.org
Periodontitis is an infectious oral disease, which leads to the destruction of periodontal
tissues and tooth loss. Although the treatment of periodontitis has improved recently, the …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

[HTML][HTML] Plant-derived exosomes as a drug-delivery approach for the treatment of inflammatory bowel disease and colitis-associated cancer

Y Cai, L Zhang, Y Zhang, R Lu - Pharmaceutics, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes
Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the …