Role of gut dysbiosis in liver diseases: what have we learned so far?

H Fukui - Diseases, 2019 - mdpi.com
Accumulating evidence supports that gut dysbiosis may relate to various liver diseases.
Alcoholics with high intestinal permeability had a decrease in the abundance of …

Effects of antibiotic therapy in primary sclerosing cholangitis with and without inflammatory bowel disease: a systematic review and meta-analysis

A Shah, D Crawford, D Burger, N Martin… - Seminars in Liver …, 2019 - thieme-connect.com
The authors conducted a systematic review and meta-analysis to assess the effect of
antibiotic therapy in primary sclerosing cholangitis (PSC). Effect of antibiotic therapy on …

Targeting the gut microbiome as a treatment for primary sclerosing cholangitis: a conceptional framework

A Shah, GA Macdonald, M Morrison… - Official journal of the …, 2020 - journals.lww.com
Primary sclerosing cholangitis (PSC) is a rare, immune-mediated, chronic cholestatic liver
disease associated with a unique phenotype of inflammatory bowel disease that frequently …

The gut–liver axis in chronic liver disease: A macrophage perspective

K De Muynck, B Vanderborght, H Van Vlierberghe… - Cells, 2021 - mdpi.com
Chronic liver disease (CLD) is a growing health concern which accounts for two million
deaths per year. Obesity, alcohol overconsumption, and progressive cholestasis are …

[HTML][HTML] Age trends in biliary tract cancer incidence by anatomical subtype: a Swedish cohort study

R Rahman, JF Ludvigsson, E von Seth… - European Journal of …, 2022 - Elsevier
Abstract Aim Studies from Western countries suggest that early-onset biliary tract cancer, a
rare malignancy originating from the bile ducts (cholangiocarcinoma) or gallbladder, is …

Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis

Y Lapidot, A Amir, S Ben-Simon, E Veitsman… - Hepatology …, 2021 - Springer
Background Primary sclerosing cholangitis (PSC) is a chronic, progressive liver disease
known for its frequent concurrence with inflammatory bowel disease. PSC can progress to …

The management of cholestatic liver diseases: current therapies and emerging new possibilities

M Mazzetti, G Marconi, M Mancinelli… - Journal of clinical …, 2021 - mdpi.com
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two chronic
cholestatic liver diseases affecting bile ducts that may progress to biliary cirrhosis. In the past …

PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic …

M Trauner, C Chung, K Sterling, X Liu, X Lu, J Xu… - BMC …, 2023 - Springer
Background Primary sclerosing cholangitis (PSC) is a chronic progressive liver disease
leading to biliary fibrosis and cirrhosis. Cilofexor is a nonsteroidal farnesoid X receptor …

Determining the indeterminate biliary stricture: cholangioscopy and beyond

NS Martinez, AJ Trindade, DV Sejpal - Current Gastroenterology Reports, 2020 - Springer
Abstract Purpose of Review Indeterminate biliary strictures (IDBS) continue to be an area of
frustration for clinicians. Standard endoscopic retrograde cholangiopancreatography …

[HTML][HTML] Hepatobiliary manifestations in inflammatory bowel disease: A practical approach

P Núñez, F Castro, G Mezzano, R Quera… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBD) are associated with various hepatobiliary disorders.
They can occur at any moment in the course of the disease or associated with the treatment …