Circuits and functions of the lateral habenula in health and in disease
H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …
owing to new discoveries relating to its critical role in regulating negatively motivated …
Dopamine and addiction
RA Wise, MA Robble - Annual review of psychology, 2020 - annualreviews.org
Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is
usually defined by characteristics of intoxication or by characteristics of withdrawal …
usually defined by characteristics of intoxication or by characteristics of withdrawal …
Drug-induced conditioned place preference and its practical use in substance use disorder research
G McKendrick, NM Graziane - Frontiers in behavioral neuroscience, 2020 - frontiersin.org
The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …
study the role of context associations in reward-related behaviors, including both natural …
Understanding addiction using animal models
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …
extraordinary global economic impact. Despite decades of research, the options available to …
Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons
Ventral tegmental area (VTA) dopamine (DA) neurons have been implicated in reward,
aversion, salience, cognition, and several neuropsychiatric disorders. Optogenetic …
aversion, salience, cognition, and several neuropsychiatric disorders. Optogenetic …
Single rodent mesohabenular axons release glutamate and GABA
The lateral habenula (LHb) is involved in reward, aversion, addiction and depression
through descending interactions with several brain structures, including the ventral …
through descending interactions with several brain structures, including the ventral …
[HTML][HTML] Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Dopamine neurons located in the midbrain play a role in motivation that regulates approach
behavior (approach motivation). In addition, activation and inactivation of dopamine neurons …
behavior (approach motivation). In addition, activation and inactivation of dopamine neurons …
A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward
Lateral habenula (LHb) neurons convey aversive and negative reward conditions through
potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although …
potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although …
The emergence of a circuit model for addiction
C Lüscher - Annual review of neuroscience, 2016 - annualreviews.org
Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue
to do so despite negative consequences. Even after prolonged periods of abstinence …
to do so despite negative consequences. Even after prolonged periods of abstinence …
A multistep general theory of transition to addiction
PV Piazza, V Deroche-Gamonet - Psychopharmacology, 2013 - Springer
Background Several theories propose alternative explanations for drug addiction. Objectives
We propose a general theory of transition to addiction that synthesizes knowledge …
We propose a general theory of transition to addiction that synthesizes knowledge …