Osteosarcoma is a highly aggressive and metastatic malignant tumor. It has the highest
incidence of all malignant bone tumors and is one of the most common solid tumors in …

Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones,
cartilage, muscles, tendons, and ligaments, account for a significant portion of the global …

Chemo‐immunotherapy has shown great success in boosting systemic anti‐tumor effects in
the clinic. However, cancer cells can escape the maximum impact of chemotherapy through …

The complex physiological environment in bone tissue poses a challenge to the efficient
delivery of chemotherapeutic agents for osteosarcoma (OS) treatment; hence, an efficient …

In osteosarcoma, immunotherapy often faces hurdles posed by cancer‐associated
fibroblasts (CAFs) that secrete dense extracellular matrix components and cytokines …

Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but
limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 …

Abstract Thymopentin (TP5), a clinically used immunomodulatory pentapeptide, can
efficiently promote thymocyte differentiation and influence mature T-cell function, thus …

The reconstruction of bone defects following bone tumor resection pose significant
challenges, including high risks for tumor recurrence. To address these challenges, we …

Background Lung cancer is one of the most frequent causes of cancer-related deaths
worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable …

Osteosarcoma, the most common bone malignancy in children and adolescents, poses
considerable challenges in terms of prognosis, especially for patients with metastatic or …