Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

Objective Natural killer (NK) cells play a critical role in the innate antitumor immune
response. Recently, NK cell dysfunction has been verified in various malignant tumors …

Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …

Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …

Hepatocellular carcinoma (HCC) is one of the most lethal tumors in China and worldwide,
although first-line therapies for HCC, such as atezolizumab and bevacizumab, have been …

Checkpoint blockade therapy, for example using antibodies against CTLA-4 and PD-1/PD-
L1, relieves T cells from the suppression by inhibitory checkpoints in the tumor …

Simple Summary Recent years marked the discovery and increased understanding of the
role immune checkpoints play in immunity against cancer. This has revolutionized cancer …