Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

RAD51 and the breast cancer suppressor BRCA2 have critical functions in DNA double-
strand (dsDNA) break repair by homologous recombination and the protection of newly …

Homologous recombination (HR) is a major pathway to repair DNA double-strand breaks
(DSB). HR uses an undamaged homologous DNA sequence as a template for copying the …

Using CRISPR-Cas9 nicking enzymes, we examined the interaction between the replication
machinery and single-strand breaks, one of the most common forms of endogenous DNA …