The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential …
H Zalpoor, A Akbari, A Samei… - Cellular & Molecular …, 2022 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …
[HTML][HTML] An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
[HTML][HTML] The Jak/STAT pathway: A focus on pain in rheumatoid arthritis
LS Simon, PC Taylor, EH Choy, A Sebba… - Seminars in arthritis and …, 2021 - Elsevier
Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …
The Role of the JAK/STAT signaling pathway in the pathogenesis of alzheimer's disease: new potential treatment target
M Rusek, J Smith, K El-Khatib, K Aikins… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease is characterized by the accumulation of amyloid plaques and
neurofibrillary tangles in the brain. However, emerging evidence suggests that …
neurofibrillary tangles in the brain. However, emerging evidence suggests that …
Microglia mediated neuroinflammation: focus on PI3K modulation
Immune activation in the central nervous system involves mostly microglia in response to
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory …
Inflammation and Alzheimer's disease: mechanisms and therapeutic implications by natural products
Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event
making the disease difficult to diagnose and treat. The pathological hallmarks of AD include …
making the disease difficult to diagnose and treat. The pathological hallmarks of AD include …
[HTML][HTML] Different approaches to modulation of microglia phenotypes after spinal cord injury
E Akhmetzyanova, K Kletenkov… - Frontiers in systems …, 2019 - frontiersin.org
Microglial cells, which are highly plastic, immediately respond to any change in the
microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or …
microenvironment by becoming activated and shifting the phenotype toward neurotoxicity or …
[HTML][HTML] Vitamin D and its potential interplay with pain signaling pathways
About 50 million of the US adult population suffer from chronic pain. It is a complex disease
in its own right for which currently available analgesics have been deemed woefully …
in its own right for which currently available analgesics have been deemed woefully …
Neuroinflammation, mast cells, and glia: dangerous liaisons
The perspective of neuroinflammation as an epiphenomenon following neuron damage is
being replaced by the awareness of glia and their importance in neural functions and …
being replaced by the awareness of glia and their importance in neural functions and …
[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …