Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest
insects, leading to toxic effects, has surfaced as a promising new control strategy in the past …

RNA interference (RNAi) is an endogenous, sequence‐specific gene‐silencing mechanism
elicited by small RNA molecules. RNAi is a powerful reverse genetic tool, and is currently …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Two decades of research on RNA interference (RNAi) have transformed a breakthrough
discovery in biology into a robust platform for a new class of medicines that modulate mRNA …

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …

Clustered regularly interspaced short palindromic repeat (CRISPR) are essential
components of nucleic-acid-based adaptive immune systems that are widespread in …