The field of “circadian medicine” is a recent addition to chronobiology and sleep research
efforts. It represents a logical step arising from the increasing insights into the circadian …

Abstract Circadian (~ 24 h) rhythms in physiology and behavior are evolutionarily conserved
and found in almost all living organisms. The rhythms are endogenously driven by daily …

Importance Postoperative sleep disturbance (PSD) is common in patients after surgery.
Objective To examine the effect of intraoperative esketamine infusion on the incidence of …

A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping
machinery known as the circadian clock (biological clock), which enables to anticipate …

Prolonged exposure (PE) therapy aiming to promote fear extinction is a useful treatment for
post-traumatic stress disorder (PTSD). However, the mechanisms underlying fear extinction …

Alterations in circadian sleep patterns constitute a salient manifestation in major depressive
disorder. GW117, an emergent antidepressant, functions as an agonist for melatonin 1 and …

Background Sleep deprivation (SD) has been suggested to have a rapid antidepressant
effect. There is substantial evidence that neuroinflammation and neuroplasticity play critical …

Background Although the disturbance of circadian rhythms represents a significant clinical
feature of major depressive disorder (MDD), the relationship between biological rhythm …

Background Patients with major depression exhibit circadian disturbance of sleep and
mood, and when they are discharged from inpatient wards, this disturbance poses a risk of …

Circadian rhythms orchestrate brain function and mental wellbeing. We compared circadian
patterns derived from continuous measurements of body temperature, sleep actigraphy and …