Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

During natural tissue regeneration, tissue microenvironment and stem cell niche including
cell–cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of …

The rational design of drug delivery approaches leveraging supramolecular chemistry
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …

Polymers, ceramics and metals have historically dominated the application of materials in
medicine. Yet rationally designed materials that exploit specific, directional, tunable and …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

Conspectus Peptide amphiphiles (PAs) are small molecules that contain hydrophobic
components covalently conjugated to peptides. In this Account, we describe recent …

In the human body, many soft tissues with hierarchically ordered composite structures, such
as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic …

Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

Aligned topographical cue has been demonstrated as a critical role in neuronal guidance,
and it is highly beneficial to develop a scaffold with aligned structure for peripheral nerve …