Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
Regioselective synthesis and computational calculation studies of some new pyrazolyl‐pyridine and bipyridine derivatives
Abstract Starting from 3‐oxo‐N‐(3‐pyridyl) butanamide, as key intermediate, the title
compounds were synthesized in good yields. Reaction of the pyridine‐carboxamide 1 with …
compounds were synthesized in good yields. Reaction of the pyridine‐carboxamide 1 with …
Synthesis of novel mono-and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition
Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-
acetylnaphthalene and was used as a new key building block for constructing the title …
acetylnaphthalene and was used as a new key building block for constructing the title …
Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through dual …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors
The target mono-and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …
Nanogenosensors based on aptamers and peptides for bioelectrochemical cancer detection: an overview of recent advances in emerging materials and technologies
BM Kangarshahi, SM Naghib - Discover Applied Sciences, 2024 - Springer
Electrochemical biosensors fabricated based on nucleic acids have shown great potential
for cancer recognition because of their low cost, fast feedback, high sensitivity, and easy …
for cancer recognition because of their low cost, fast feedback, high sensitivity, and easy …
[HTML][HTML] Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid …
IMZ Fares, NE Mahmoud, IA Abdelhamid… - Results in …, 2024 - Elsevier
Bacterial infections are a global issue, causing sickness and death, mainly in developing
nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the …
nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the …
Synthesis of novel piperazine-based bis (thiazole)(1, 3, 4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis
A series of novel piperazine-based bis (thiazoles) 13a–d were synthesized in moderate to
good yields via reaction of the bis (thiosemicarbazones) 7a, b with an assortment of C-acetyl …
good yields via reaction of the bis (thiosemicarbazones) 7a, b with an assortment of C-acetyl …
Synthesis, molecular docking, and antimicrobial activity of novel scaffolds based on bis (thiazole) linked to 2-phenoxy-N-arylacetamide as new hybrid molecules
AH Abdullah, NS Ibrahim, FK Algethami… - Journal of Molecular …, 2024 - Elsevier
The reaction of the appropriate bis (α-haloketones) with the corresponding
thiosemicarbazones in EtOH at reflux in the presence of a few drops of TEA produced good …
thiosemicarbazones in EtOH at reflux in the presence of a few drops of TEA produced good …
1,3-(4,4'-dipyridinium disulfonic acid)propane dimethanesulfonate as an effective double-functional catalyst in preparing N,N′-Methylene bisamides …
EAM Saleh, BM Abdullah, HK Mohammed… - Research on Chemical …, 2024 - Springer
In this paper, a dual-functional Brønsted acidic ionic liquid (BAIL) catalyst, namely 1, 3-(4, 4'-
dipyridinium disulfonic acid) propane dimethanesulfonate (DPDSPDM), was produced, and …
dipyridinium disulfonic acid) propane dimethanesulfonate (DPDSPDM), was produced, and …