[HTML][HTML] Targeting fibrosis: Mechanisms and clinical trials

M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

[HTML][HTML] FGF/FGFR signaling in health and disease

Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

[PDF][PDF] Multipotent stromal cells: one name, multiple identities

H Soliman, M Theret, W Scott, L Hill, TM Underhill… - Cell stem cell, 2021 - cell.com
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

AL Mora, M Rojas, A Pardo, M Selman - Nature reviews Drug discovery, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

[HTML][HTML] Resolution of organ fibrosis

JI Jun, LF Lau - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …

An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis

RG Jenkins, BB Moore, RC Chambers… - American journal of …, 2017 - atsjournals.org
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International Journal of Molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

[HTML][HTML] FGF/FGFR signaling: From lung development to respiratory diseases

L Yang, F Zhou, D Zheng, D Wang, X Li, C Zhao… - Cytokine & Growth …, 2021 - Elsevier
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …