As a major cause of morbidity and mortality globally, hypertension remains a serious threat
to global public health. Despite the availability of many antihypertensive medications …

Cardiovascular diseases (CVDs) in the course of atherosclerosis are one of the most critical
public health problems in the world. Endothelial cells synthesize numerous biologically …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Abstract Purpose of Review Approximately 10% of the adults with hypertension fail to
achieve the recommended blood pressure treatment targets on 3 antihypertensive …

Dyslipidemia is a treatable risk factor for atherosclerotic cardiovascular disease that can be
addressed through lifestyle changes and/or lipid-lowering therapies. Adherence to statins …

Background and aims Epidemiological evidence of the association between migraines,
severe headaches, and hypertension is contradictory. Hypertension is a critical risk factor for …

Pulmonary arterial hypertension (PAH) is a severe medical condition characterized by
elevated blood pressure in the pulmonary arteries. Nitric oxide (NO) is a gaseous signaling …

Hypertension is one of the foremost risk factors for cardiovascular disease and a significant
cause of death worldwide. Importantly, endothelial dysfunction (ED) is one of the primary …

Mitochondrial dysfunction in the endothelium contributes to the progression of hypertension
and plays an obligatory role in modulating vascular tone. Acacetin is a natural flavonoid …