Targeting drug delivery in the vascular system: Focus on endothelium
PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …
site of administration to the intended site of action. In many cases, components of the …
Focus on fundamentals: achieving effective nanoparticle targeting
Successful molecular targeting of nanoparticle drug carriers can enhance therapeutic
specificity and reduce systemic toxicity. Typically, ligands specific for cognate receptors …
specificity and reduce systemic toxicity. Typically, ligands specific for cognate receptors …
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
OA Marcos-Contreras, CF Greineder… - Proceedings of the …, 2020 - National Acad Sciences
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …
Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys
GT Tietjen, SA Hosgood, J DiRito, J Cui… - Science translational …, 2017 - science.org
Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …
Targeting vascular inflammation through emerging methods and drug carriers
Acute inflammation is a common dangerous component of pathogenesis of many prevalent
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …
Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies
We postulate that nanoparticles (NPs) for use in therapeutic applications have largely not
realized their clinical potential due to an overall inability to use in vitro results to predict NP …
realized their clinical potential due to an overall inability to use in vitro results to predict NP …
Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury
Following traumatic brain injury (TBI), reactive oxygen species (ROS) are released in
excess, causing oxidative stress, carbonyl stress, and cell death, which induce the additional …
excess, causing oxidative stress, carbonyl stress, and cell death, which induce the additional …
Expanding the arsenal against pulmonary diseases using surface-functionalized polymeric micelles: Breakthroughs and bottlenecks
Pulmonary diseases such as lung cancer, asthma and tuberculosis have remained one of
the common challenges globally. Polymeric micelles (PMs) have emerged as an effective …
the common challenges globally. Polymeric micelles (PMs) have emerged as an effective …
Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology
Nanoparticles in the bloodstream are subjected to complex fluid forces as they move
through the curves and branches of healthy or tumor vasculature. While nanoparticles are …
through the curves and branches of healthy or tumor vasculature. While nanoparticles are …
Targeting therapeutics to endothelium: are we there yet?
Vascular endothelial cells represent an important therapeutic target in many pathologies,
including inflammation, oxidative stress, and thrombosis; however, delivery of drugs to this …
including inflammation, oxidative stress, and thrombosis; however, delivery of drugs to this …