Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …

We studied human immunodeficiency virus, type 1 (HIV-1) integrase (IN) complexes derived
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …

We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75,
which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant …

Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an
important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer …

Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We
examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells …

The insertion of a DNA copy of its RNA genome into a chromosome of the hostcell is
mediated by the viral integrase with the help of mostlyuncharacterized cellular cofactors. We …

In order to replicate, human immunodeficiency virus (HIV‐1) reverse‐transcribes its RNA
genome into DNA, which subsequently integrates into host cell chromosomes. These two …

HIV-1 is able to infect nondividing cells productively in part because the postentry viral
nucleoprotein complexes are actively imported into the nucleus. In this manuscript, we …