The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …

The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and
macromolecules. The major macromolecular components of mucus are the mucin …

Rationale: E-cigarettes have become increasingly popular and little is known about their
potential adverse health effects. Objectives: To determine the effects of e-cigarette use on …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Knowing the physicochemical properties of exhaled droplets and aerosol particles is a
prerequisite for a detailed mechanistic understanding and effective prevention of the …

Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus
layer of human airways. Each mucin has distinct functions and site-specific expression …