Evaluating long-term cellular effects of the arsenic species thio-DMAV: qPCR-based gene expression as screening tool

F Ebert, M Thomann, B Witt, SM Müller, S Meyer… - Journal of Trace …, 2016 - Elsevier
Thio-dimethylarsinic acid (thio-DMA V) is a human urinary metabolite of the class 1 human
carcinogen inorganic arsenic as well as of arsenosugars. Thio-DMA V exerts strong cellular …

Proposal for novel metabolic pathway of highly toxic dimethylated arsenics accompanied by enzymatic sulfuration, desulfuration and oxidation

Y Shimoda, H Kurosawa, K Kato, Y Endo… - Journal of Trace …, 2015 - Elsevier
Abstract The International Agency for Research on Cancer (IARC) has concluded that
dimethylarsinic acid [(CH 3) 2 AsO (OH), DMA V], a main metabolite of inorganic arsenic, is …

Changing concept of arsenic toxicity with development of speciation techniques

BK Mandal - Handbook of arsenic toxicology, 2023 - Elsevier
Arsenic (As), being a metalloid, is well known for its versatile applications to mankind.
Arsenic is coined by USEPA as the number one carcinogen. The human body can …

Differences in apoptotic signaling and toxicity between dimethylmonothioarsinic acid (DMMTAV) and its active metabolite, dimethylarsinous acid (DMAIII), in HepaRG …

Y Shimoda, K Kato, S Asami, M Kurita… - Journal of Trace …, 2018 - Elsevier
Dimethylmonothioarsinical acid (DMMTA V), a metabolite of arsenosugars (AsSug) and
arsenolipids (AsLP), which are major organoarsenicals contained in seafoods, has been a …

Molecular imaging of nuclear factor-κB in bladder as a primary regulator of inflammatory response

EV Vykhovanets, GT MacLennan… - The Journal of …, 2012 - auajournals.org
Purpose: Nuclear factor-κB activation is implicated in chronic inflammatory disorders and it is
a key regulator of genes involved in the response to infection, inflammation and stress …

Oxidative/Nitrosative Stress, 8-OHdG and MMP-9: The Possible Co-Links and Early Sign of Arsenic Induced Urinary Bladder Carcinogenesis in Experimental Rats

KB Sathua, JK Patwa, SJS Flora - Free radicals and antioxidants, 2019 - mail.antiox.org
Background: Presently arsenicosis is considered as dangerous health issues including
cancer. Urinary bladder is one of the common target organs for developing carcinogenesis …

The Enhancing Effect of the Antioxidant N-Acetylcysteine on Urinary Bladder Injury Induced by Dimethylarsinic Acid

N Takahashi, T Yoshida, A Ohnuma… - Toxicologic …, 2011 - journals.sagepub.com
Dimethylarsinic acid (DMAV), the major excreted metabolite of inorganic arsenic, is
carcinogenic to the rat urinary bladder. Oxidative stress has been proposed as one possible …

Speciation of arsenic metabolites in the free-living mouse Mus spretus from Doñana National Park used as a bio-indicator for environmental pollution monitoring

MÁ García-Sevillano, M González-Fernández… - Chemical Papers, 2012 - Springer
A speciation approach based on orthogonal chromatographic systems coupled to
inductively coupled plasma mass spectrometry (ICP-MS) was used to characterise the …

Formation of dimethyldithioarsinic acid in a simulated landfill leachate in relation to hydrosulfide concentration

J An, KH Kim, M Kong, JA Kim, JH Shin, YG Ahn… - … geochemistry and health, 2016 - Springer
Dimethyldithioarsinic acid (DMDTA V), present in such intense sources as municipal landfill
leachate, has drawn a great deal of attention due to its abundant occurrence and different …

Arsenic and its Inorganic Compounds (with the Exception of Arsine)[MAK Value Documentation, 2014]

A Hartwig, MAK Commission - The MAK‐Collection for …, 2002 - Wiley Online Library
The German Commission for the Investigation of Health Hazards of Chemical Compounds in
the Work Area has re‐evaluated arsenic and its inorganic compounds, with a special focus …