The immunology of multiple sclerosis

KE Attfield, LT Jensen, M Kaufmann… - Nature Reviews …, 2022 - nature.com
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications

K Bjornevik, C Münz, JI Cohen, A Ascherio - Nature Reviews Neurology, 2023 - nature.com
Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

Epstein-Barr virus and multiple sclerosis

G Houen, NH Trier, JL Frederiksen - Frontiers in immunology, 2020 - frontiersin.org
Multiple sclerosis (MS) is a neurologic disease affecting myelinated nerves in the central
nervous system (CNS). The disease often debuts as a clinically isolated syndrome, eg, optic …

Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom

A Kuri, BM Jacobs, N Vickaryous, J Pakpoor… - BMC public health, 2020 - Springer
Abstract Background Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with
which~ 95% of the healthy population is infected. EBV infection has been implicated in a …

[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Association between human herpesviruses and multiple sclerosis: A systematic review and meta-analysis

Z Khalesi, V Tamrchi, MH Razizadeh, A Letafati… - Microbial …, 2023 - Elsevier
Aim The aim of this study was to investigate the prevalence and potential association
between infection with different herpes viruses and multiple sclerosis (MS). Methods A …

Origins and immunopathogenesis of autoimmune central nervous system disorders

S Ramanathan, F Brilot, SR Irani, RC Dale - Nature Reviews Neurology, 2023 - nature.com
The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

[HTML][HTML] Review of the COVID-19 risk in multiple sclerosis

F Chaudhry, C Jageka, PD Levy… - Journal of cellular …, 2021 - ncbi.nlm.nih.gov
The ongoing pandemic of the novel coronavirus of 2019 (COVID-19) has resulted in over 1
million deaths, primarily affecting older patients with chronic ailments. Multiple sclerosis …

The role of Epstein-Barr virus in the etiology of multiple sclerosis: a current review

K Ruprecht - Expert review of clinical immunology, 2020 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the
central nervous system. While its exact etiology is unknown, it is generally believed that MS …