Effect of meropenem administration in extended infusion on the clinical outcome of febrile neutropenia: a retrospective observational study
Objectives Information on the efficacy of extended meropenem administration in neutropenic
patients is scarce. Our objective was to determine whether the administration of meropenem …
patients is scarce. Our objective was to determine whether the administration of meropenem …
Evaluation of meropenem‐ciprofloxacin combination dosage regimens for the pharmacokinetics of critically ill patients with augmented renal clearance
AA Agyeman, KE Rogers, JR Tait… - Clinical …, 2021 - Wiley Online Library
Augmented renal clearance (ARC, creatinine clearance> 130 mL/minute) makes difficult
achievement of effective concentrations of renally cleared antibiotics in critically ill patients …
achievement of effective concentrations of renally cleared antibiotics in critically ill patients …
The exploration of population pharmacokinetic model for meropenem in augmented renal clearance and investigation of optimum setting of dose
T Tamatsukuri, M Ohbayashi, N Kohyama… - Journal of Infection and …, 2018 - Elsevier
In recent years, augmented renal clearance (ARC), in which renal function is excessively
enhanced, has been reported, and its influence on β-lactam antibiotics has been …
enhanced, has been reported, and its influence on β-lactam antibiotics has been …
Substantial impact of altered pharmacokinetics in critically ill patients on the antibacterial effects of meropenem evaluated via the dynamic hollow-fiber infection model
Critically ill patients frequently have substantially altered pharmacokinetics compared to non-
critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial …
critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial …
Pharmacokinetic variability of beta-lactams in critically ill patients: a narrative review
C Boidin, P Moshiri, C Dahyot-Fizelier… - … Critical Care & Pain …, 2020 - Elsevier
The use of antibacterial drugs is very common in critically ill patients and beta-lactam agents
are widely used in this context. Critically ill patients show several characteristics (eg, sepsis …
are widely used in this context. Critically ill patients show several characteristics (eg, sepsis …
Prolonged infusion antibiotics for suspected gram-negative infections in the ICU: a before-after study
HM Arnold, JM Hollands, LP Skrupky… - Annals of …, 2013 - journals.sagepub.com
BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged
infusion of these agents is commonly performed to optimize the time the unbound …
infusion of these agents is commonly performed to optimize the time the unbound …
Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous …
JM Varghese, P Jarrett, RJ Boots… - International journal of …, 2014 - Elsevier
This prospective pharmacokinetic study aimed to describe plasma and interstitial fluid (ISF)
pharmacokinetics of piperacillin and tazobactam in critically ill patients on continuous …
pharmacokinetics of piperacillin and tazobactam in critically ill patients on continuous …
Pharmacokinetics and pharmacodynamics in critically ill patients
JM Varghese, JA Roberts, J Lipman - Current Opinion in …, 2010 - journals.lww.com
Studies have shown that critically ill patients display large variations in pharmacokinetics
mainly due to altered pathophysiology. An understanding of the pathophysiological changes …
mainly due to altered pathophysiology. An understanding of the pathophysiological changes …
Extended infusion of β-lactams for bloodstream infection in patients with liver cirrhosis: an observational multicenter study
M Bartoletti, M Giannella, RE Lewis… - Clinical Infectious …, 2019 - academic.oup.com
Background We analyzed the impact of continuous/extended infusion (C/EI) vs intermittent
infusion of piperacillin-tazobactam (TZP) and carbapenems on 30-day mortality of patients …
infusion of piperacillin-tazobactam (TZP) and carbapenems on 30-day mortality of patients …
Meropenem combined with ciprofloxacin combats hypermutable Pseudomonas aeruginosa from respiratory infections of cystic fibrosis patients
Hypermutable Pseudomonas aeruginosa organisms are prevalent in chronic respiratory
infections and have been associated with reduced lung function in cystic fibrosis (CF); these …
infections and have been associated with reduced lung function in cystic fibrosis (CF); these …