Background Optimal antimicrobial drug exposure in the lung is required for successful
treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary …

Sir, Administration of b-lactams by continuous infusion is gaining popularity as a simple
approach to optimize their efficacy [the percentage of the dosing interval during which the …

There is strong evidence in literature supporting the benefit of monitoring plasma
concentrations of β-lactam antibiotics in the critically ill to ensure appropriateness of dosing …

Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity:
in humans, genetic variations account for a relevant proportion of such variability. In the last …

Management of nosocomial pneumonia is frequently complicated by bacterial resistance.
Extended infusions of beta-lactams are increasingly being used to improve clinical …

The objectives of this study were to describe meropenem pharmacokinetics (PK) in plasma
and/or subcutaneous adipose tissue (SCT) in critically ill patients receiving extracorporeal …

This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In
this observational study, serial blood samples were taken over several dosing intervals of …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Although early and appropriate antibiotic therapy remains the cornerstone of success for the
treatment of septic shock, few data exist to guide antibiotic dose optimization in critically ill …

Purpose To develop a meropenem population pharmacokinetic model in critically ill patients
with particular focus on optimizing dosing regimens based on renal function. Methods …