Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Objective: Doripenem is a valuable broad-spectrum antibiotic for empirical therapy in
critically ill patients, although little data exist to guide effective dosing. We sought to describe …

Infections and related sepsis are two of the most prevalent issues in the care of critically ill
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …

The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients
exhibit marked variability. This variability results from pathophysiological changes that occur …

Background: Gram-negative bacteria are associated with significant morbidity and mortality
in preterm and term newborns. Meropenem has widespread efficacy and often allows for …

This is a guideline for the management of sepsis, developed by the Sepsis Registry
Committee of The Japanese Society of Intensive Care Medicine (JSICM) launched in March …

Objectives The objective of this study was to propose an optimal treatment regimen of
meropenem in critically ill patients with severe nosocomial pneumonia. Patients and …

Background Ventriculitis is a complication of temporary intraventricular drains. The limited
penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However …

Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …