Spatiotemporal control of acetyl-CoA metabolism in chromatin regulation
S Sivanand, I Viney, KE Wellen - Trends in biochemical sciences, 2018 - cell.com
The epigenome is sensitive to the availability of metabolites that serve as substrates of
chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation …
chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation …
The metabolic fate of acetate in cancer
Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-
CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been …
CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been …
[HTML][HTML] Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
[HTML][HTML] Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2)
contributes to cancer cell growth under low-oxygen and lipid-depleted conditions …
contributes to cancer cell growth under low-oxygen and lipid-depleted conditions …
[HTML][HTML] Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
T Mashimo, K Pichumani, V Vemireddy, KJ Hatanpaa… - Cell, 2014 - cell.com
Glioblastomas and brain metastases are highly proliferative brain tumors with short survival
times. Previously, using 13 C-NMR analysis of brain tumors resected from patients during …
times. Previously, using 13 C-NMR analysis of brain tumors resected from patients during …
[HTML][HTML] Acetate dependence of tumors
SA Comerford, Z Huang, X Du, Y Wang, L Cai… - Cell, 2014 - cell.com
Acetyl-CoA represents a central node of carbon metabolism that plays a key role in
bioenergetics, cell proliferation, and the regulation of gene expression. Highly glycolytic or …
bioenergetics, cell proliferation, and the regulation of gene expression. Highly glycolytic or …
[HTML][HTML] ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and
can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy …
can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy …
[HTML][HTML] Memory CD8+ T cells require increased concentrations of acetate induced by stress for optimal function
How systemic metabolic alterations during acute infections impact immune cell function
remains poorly understood. We found that acetate accumulates in the serum within hours of …
remains poorly understood. We found that acetate accumulates in the serum within hours of …
Acetate metabolism in physiology, cancer, and beyond
Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous
metabolic functions, including energy production, lipid synthesis, and protein acetylation …
metabolic functions, including energy production, lipid synthesis, and protein acetylation …
[HTML][HTML] Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Background Cell growth requires fatty acids for membrane synthesis. Fatty acids are
assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen …
assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen …