The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Simple Summary Hepatocellular carcinoma (HCC) is the most frequent primitive cancer of
the liver, accounting for 90% of all recorded cases. HCC is the third most common cause of …

Background: VEGFR-2 is a key regulator of cancer cell proliferation, migration and
angiogenesis. Aim: Development of thieno [2, 3-d] pyrimidine derivatives as potential anti …

Receptor oligomerization is a highly complex molecular process that modulates divergent
cell signaling. However, there is a lack of molecular tools for systematically interrogating …

Single-pass transmembrane receptors (SPTMRs) represent a diverse group of integral
membrane proteins that are involved in many essential cellular processes, including signal …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Tendon injuries suffer from a slow healing, often ending up in fibrovascular scar formation,
leading to inferior mechanical properties and even re-rupture upon resumption of daily work …

In this study, novel VEGFR-2-targeting thiazolidine-2, 4-dione derivatives with potential
anticancer properties were designed and synthesized. The ability of the designed …