Effect of temperature and solvent of solvent-mediated polymorph transformation on ASP3026 polymorphs and scale-up
K Takeguchi, K Obitsu, S Hirasawa, R Orii… - … Process Research & …, 2016 - ACS Publications
ASP3026 (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl}-N′-[2-
(propane-2-sulfonyl) phenyl]-1, 3, 5-triazine-2, 4-diamine) was developed as a novel and …
(propane-2-sulfonyl) phenyl]-1, 3, 5-triazine-2, 4-diamine) was developed as a novel and …
Improved Manufacturing Route and Polymorphic Control of a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor ASP3026
Y Takahama, K Obitsu, K Takeguchi… - … Process Research & …, 2019 - ACS Publications
Our effort toward the process improvement of anaplastic lymphoma kinase (ALK) inhibitor
ASP3026 (1) is described. A cost-effective and practical synthesis of 1 was accomplished as …
ASP3026 (1) is described. A cost-effective and practical synthesis of 1 was accomplished as …
Synthesis, structure and properties of polymorphic modifications of bioactive molecules
Y Vaksler - 2021 - theses.hal.science
Active pharmaceutical ingredients can retain their properties constant indefinitely in a solid
state. As a result, numerous drugs are produced and stored in the most stable solid phase …
state. As a result, numerous drugs are produced and stored in the most stable solid phase …