Regardless of progress in therapy management which are developed for colon cancer (CC),
it remains the third most common cause of mortality due to cancers around the world …

CPT-11 (irinotecan), a DNA topoisomerase I inhibitor is one of the main treatments for
colorectal cancer. The main dose limiting toxicities are neutropenia and late onset diarrhea …

Oral chemotherapy is the preferred treatment for colon cancer. However, this strategy faces
many challenges, including instability in the gastrointestinal (GI) tract, insufficient …

For cancer chemotherapy, a tumor regression without any surgical resection and severe
side effects is greatly preferred to merely slowing down the growth of tumors. Here, we report …

Intestinal damage and severe diarrhea are serious side effects of cancer chemotherapy and
constrain the usage of most such therapies. Here we show that interleukin-33 (IL-33) …

Purpose: An antitumor camptothecin derivative CPT-11 has proven a broad spectrum of
solid tumor malignancy, but its severe diarrhea has often limited its more widespread use …

We have recently reported a chemical approach for half-life extension that utilizes β-
eliminative linkers to attach amine-containing drugs or prodrugs to macromolecules. The …

Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in
particular for drugs such as irinotecan (CPT-11), 5-fluouracil, oxaliplatin, capecitabine and …

The incidence of autoimmune diseases has significantly increased over the past 20 years.
Excessive host immunoreactions and disordered immunoregulation are at the core of the …

Oral mucositis (OM) is a common complication in cancer patients undergoing anticancer
treatment. Despite the clinical and economic consequences of OM, there are no drugs …