5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Comorbidity is a major issue in psychiatry that notably associates with more severe
symptoms, longer illness duration, and higher service utilization. Therefore, identifying key …

Dopamine replacement therapy with l-DOPA is the most efficacious symptomatic treatment
for Parkinson's disease, but its utility is limited by a development of motor fluctuations and …

Pupil dilation is mediated by a sympathetic output acting in opposition to
parasympathetically mediated pupil constriction. While light stimulates the parasympathetic …

Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

G protein-coupled receptors (GPCRs) coupling to G i/o signaling pathways are involved in
the control of important physiological functions, which are difficult to investigate because of …

Alcohol-use-disorders are chronic relapsing illnesses, often co-morbid with anxiety. We
have previously shown using the “drinking-in-the-dark” model in mice that the stimulation of …

Several lines of evidence implicate serotonin (5-hydroxytryptamine, 5-HT) in regulating
personality traits and mood control. Serotonergic neurons are classically thought to be tonic …

The cannabinoid system is composed of Gi/o protein-coupled cannabinoid type 1 receptor
(CB 1) and cannabinoid type 2 (CB 2) receptor and endogenous compounds. The CB 1 …

Endocrine-disrupting compounds (EDCs) are common contaminants in our environment that
interfere with typical endocrine function. EDCs can act on steroid and nuclear receptors or …