Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most
common cause of cancer-related deaths in men. Family history of PCa, hereditary breast …

Background Risk stratification or progression in prostate cancer is performed with the
support of clinical-pathological data such as the sum of the Gleason score and serum levels …

Simple Summary Familial cancer can be defined through the occurrence of the same cancer
in two or more family members. Hereditary cancer is a narrower definition of high-risk …

Nanocarriers (NCs) have shown potential in delivering hydrophobic cytotoxic drugs and
tumor-specific targeting. However, the inability to penetrate the tumor microenvironment and …

Introduction Hypoxia-inducible factor (HIF) mediates multiple intracellular processes that
drive cellular metabolism and induce proliferation. Dysregulated HIF expression is …

Abstract Background Prostate cancer (PrCa) is one of the most hereditable human cancers,
however, only a small fraction of patients has been shown to carry deleterious variants in …

Prostate cancer (PCa) is the most common non-cutaneous tumor among men worldwide
and, if diagnosed late, it exhibits a high mortality representing the sixth most lethal tumor in …

Prostate cancer (PC) is the third most frequently diagnosed cancer worldwide and the
second most frequent in men. Several risk factors can contribute to the development of PC …

Prostate cancer can significantly shorten the lifetime of a patient, even if he is diagnosed at
an early stage. The development of minimally-invasive focal therapies such as …

Large amounts of germline sequencing data have recently become available and we sought
to compare these results with population-based family history data. Family studies are able …