Graft-versus-leukemia effects of transplantation and donor lymphocytes

HJ Kolb - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even
in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) …

Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment

F Kreidieh, I Abou Dalle, N Moukalled… - International Journal of …, 2022 - Springer
Despite therapeutic progress in acute myeloid leukemia (AML), relapse post-allogeneic
hematopoietic stem cell transplantation (allo-HSCT) remains a major challenge. Here, we …

Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited

A Deol, LG Lum - Cancer treatment reviews, 2010 - Elsevier
BACKGROUND: Treatment of relapsed hematological malignancies after an allogeneic
peripheral blood stem cell transplant (SCT) is challenging. Donor lymphocyte infusion (DLI) …

The allogeneic graft‐versus‐cancer effect

O Ringdén, H Karlsson, R Olsson… - British journal of …, 2009 - Wiley Online Library
Allogeneic haematological stem cell transplantation (HSCT) has developed into
immunotherapy. Donor CD4+, CD8+ and natural killer (NK) cells have been reported to …

Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

C Roddie, KS Peggs - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: Allogeneic hematopoietic stem cell transplantation (SCT) is the treatment of
choice for many malignant hematological disorders. Following recent improvements in non …

Donor lymphocyte infusion after allogeneic stem cell transplantation

L Castagna, B Sarina, S Bramanti, P Perseghin… - … and Apheresis Science, 2016 - Elsevier
Allogeneic stem cell transplantation (allo-SCT) is considered the cornerstone in the
treatment of several malignant and not malignant hematological diseases. However, relapse …

[HTML][HTML] Donor lymphocyte infusions in AML and MDS: Enhancing the graft-versus-leukemia effect

G Orti, P Barba, L Fox, O Salamero, F Bosch… - Experimental …, 2017 - Elsevier
Highlights•Donor lymphocyte infusion (DLI) provides a way to enhance the graft-versus-
leukemia effect.•GvHD represents the main toxicity after DLI.•Pre-DLI low disease burden …

Donor-derived anti-CD19 CAR T cells compared with donor lymphocyte infusion for recurrent B-ALL after allogeneic hematopoietic stem cell transplantation

J Hua, J Zhang, X Zhang, X Wu, L Zhou… - Bone Marrow …, 2021 - nature.com
The efficacy and safety of donor-derived anti-CD19 CAR T cells vs DLI for the management
of relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allo-hematopoietic stem cell …

Donor leukocyte infusions for the treatment of relapsed acute leukemia after allogeneic stem cell transplantation

AW Loren, DL Porter - Bone marrow transplantation, 2008 - nature.com
Allogeneic stem cell transplantation (SCT) offers the only hope for cure for many adults with
acute leukemia. Unfortunately, many patients relapse and die of their disease even after …

[HTML][HTML] Donor lymphocyte infusion for the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: a retrospective …

A Takami, S Yano, H Yokoyama, Y Kuwatsuka… - Biology of Blood and …, 2014 - Elsevier
Because the efficacy of donor lymphocyte infusion (DLI) for acute myeloid leukemia (AML)
relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains uncertain …