Antiviral therapy of COVID-19

G Gudima, I Kofiadi, I Shilovskiy, D Kudlay… - International Journal of …, 2023 - mdpi.com
Since the beginning of the COVID-19 pandemic, the scientific community has focused on
prophylactic vaccine development. In parallel, the experience of the pharmacotherapy of this …

Synthesis of nucleoside-boronic esters hydrophobic pro-drugs: A possible route to improve hydrophilic nucleoside drug loading into polymer nanoparticles

Y Abo-zeid, G Mantovani, WL Irving… - Journal of Drug Delivery …, 2018 - Elsevier
Nucleoside analogues are active therapeutic agents for different types of diseases eg
Cancer and virus infections. However, they are associated with several side effects due to off …

Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E

OA Adaramoye, OM Adewumi… - Journal of basic and …, 2012 - degruyter.com
Background: Tenofovir (TFR) is a nucleotide reverse transcriptase inhibitor with activity
against human immunodeficiency virus. We studied the effect of TFR administered to Wistar …

Unraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model

LM Mangus, JL Dorsey, VA Laast, M Ringkamp… - ILAR …, 2014 - academic.oup.com
Peripheral neuropathy (PN) is the most frequent neurologic complication in individuals
infected with human immunodeficiency virus (HIV). It affects over one third of infected …

NRTI backbone in HIV treatment: will it remain relevant?

R Tressler, C Godfrey - Drugs, 2012 - Springer
Nucleoside reverse transcriptase inhibitors (NRTIs) remain a critical component of therapy
for HIV-infected patients. The drugs are effective, relatively inexpensive and an important …

Phytochemical and Pharmacological Values of Two Major Constituents of Asparagus Species and Their Nano Formulations: A Review

Y Sobhy, M Mady, S Mina… - Journal of Advanced …, 2022 - aprh.journals.ekb.eg
Objectives: This review article highlights two of the major chemical classes and their
derivatives frequently isolated from different species of genus Asparagus and the diversity of …

Understanding and avoiding antiretroviral adverse events

S Shibuyama, A Gevorkyan, U Yoo… - Current …, 2006 - ingentaconnect.com
Objective: To discuss prevention and management of adverse drug reactions which result
from antiretroviral use in patients infected with HIV. Background: There are four classes of …

Method of determining therapeutic activity and/or possible side-effects of a medicament

B Van Gemen, ECAC Timmermans… - US Patent …, 2005 - Google Patents
The invention relates to the diagnosis of disease or the determination of functioning of
cellular organisms, being of multi-cellular or unicellular nature, being Visible by the naked …

Insights into the molecular mechanism of polymerization and nucleoside reverse transcriptase inhibitor incorporation by human PrimPol

AC Mislak, KS Anderson - Antimicrobial agents and …, 2016 - Am Soc Microbiol
Human PrimPol is a newly identified DNA and RNA primase-polymerase of the archaeo-
eukaryotic primase (AEP) superfamily and only the second known polymerase in the …

HIV peripheral neuropathy: pathophysiology and clinical implications

SG Dorsey, PG Morton - AACN Advanced Critical Care, 2006 - AACN
One of the most debilitating neurological complications of human immunodeficiency virus
(HIV), affecting nearly one in three patients, is painful peripheral neuropathy. Although HIV …