An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
Thinking outside the box: non-canonical targets in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
Identification of early neurodegenerative pathways in progressive multiple sclerosis
M Kaufmann, AL Schaupp, R Sun, F Coscia… - Nature …, 2022 - nature.com
Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …
which causes cumulative disability and is refractory to current treatments. Drug development …
Single-cell RNA sequencing maps endothelial metabolic plasticity in pathological angiogenesis
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
The unique structural and functional features of CXCL12
R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …
The anatomy and immunology of vasculature in the central nervous system
P Mastorakos, D McGavern - Science immunology, 2019 - science.org
Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …
development and modulation of CNS immune responses. Structural variations in the …
The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
R Brambilla - Acta neuropathologica, 2019 - Springer
Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
Bruton's tyrosine kinase (BTK) inhibitors and autoimmune diseases: making sense of BTK inhibitor specificity profiles and recent clinical trial successes and failures
GE Ringheim, M Wampole, K Oberoi - Frontiers in immunology, 2021 - frontiersin.org
Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged
behind development of these drugs for treating cancers, due in part from concerns over the …
behind development of these drugs for treating cancers, due in part from concerns over the …
Perivascular spaces and their role in neuroinflammation
It is uncontested that perivascular spaces play critical roles in maintaining homeostasis and
priming neuroinflammation. However, despite more than a century of intense research on …
priming neuroinflammation. However, despite more than a century of intense research on …
[HTML][HTML] Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
MJ Simon, JJ Iliff - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of
solutes from the brain interstitium, serving an important homeostatic role for the function of …
solutes from the brain interstitium, serving an important homeostatic role for the function of …