Diabetes mellitus is a group of chronic metabolic disorders characterized by hyperglycemia
due to defects in insulin action and/or secretion. It is a worldwide problem which has led to …

Type 2 Diabetes (T2D) is an important cause of renal dysfunction and the most common
cause of end-stage renal disease (ESRD). Diabetic nephropathy is also associated with an …

Rationale: Phosphorylation of sarcomeric proteins has been implicated in heart failure with
preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by …

Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The
serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in …

In this study, we explored the effect of berberine treatment on the AGEs-RAGE pathway in a
rat model of diabetic nephropathy, and we investigated the mechanism by which key factors …

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype γ (PPARγ)
activators that are clinically used as an insulin sensitizer for glycemic control in patients with …

Chicken meat is among the common and relatively inexpensive source of protein consumed
worldwide from the poultry industry. Many communities show concern regarding the …

OBJECTIVE—The nuclear receptor hepatic nuclear factor 4α (HNF4α) is a master regulatory
protein and an essential player in the control of a wide range of metabolic processes …

Objective To investigate whether ruboxistaurin (a selective PKC-β inhibitor) mediates
renoprotective effect via interference with TGF-β1/Smad-GRAP cross-signalling. Method …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We previously
showed that RhoA activation by high glucose in mesangial cells (MC) leads to matrix …